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Cerebrovascular Adverse Reactions in Elderly Patients with Dementia-Related Psychosis: Increased incidence of cerebrovascular adverse reactions (e.g. stroke, transient ischemic attack, including fatalities). Neuroleptic Malignant Syndrome: Manage with immediate discontinuation and close monitoring. Tardive Dyskinesia: Discontinue if clinically appropriate. Metabolic Changes: Atypical antipsychotic drugs have been associated with metabolic changes that include hyperglycemia/diabetes mellitus, dyslipidemia, and body weight gain. Hyperglycemia/Diabetes Mellitus: Monitor glucose regularly in patients with and at risk for diabetes. Dyslipidemia: Undesirable alterations in lipid levels have been observed in patients treated with atypical antipsychotics. Weight Gain: Weight gain has been observed with atypical antipsychotic use. Monitor weight. Pathological Gambling and Other Compulsive Behaviors: Consider dose reduction or discontinuation. Falls: Antipsychotics may cause somnolence, postural hypotension, motor and sensory instability, which may lead to falls. Orthostatic Hypotension: Monitor heart rate and blood pressure and warn patients with known cardiovascular or cerebrovascular disease, and risk of dehydration or syncope. Leukopenia, Neutropenia, and Agranulocytosis: have been reported with antipsychotics including ABILIFY. Patients with a history of a clinically significant low white blood cell count (WBC or a drug-induced leukopenia/neutropenia should have their complete blood count (CBC monitored frequently during the first few months of therapy and discontinuation of ABILIFY should be considered at the first sign of a clinically significant decline in WBC in the absence of other causative factors. Seizures/Convulsions: Use cautiously in patients with a history of seizures or with conditions that lower the seizure threshold. Potential for Cognitive and Motor Impairment: Use caution when operating machinery. Suicide: The possibility of a suicide attempt is inherent in schizophrenia and bipolar disorder. Closely supervise high-risk patients.
A number of patients have filed lawsuits against Bristol-Myers Squibb and Otsuka claiming Abilify has caused compulsive behavior that has caused them physical and financial damage.
Patients who are injured by defective drugs may be able to seek damages from the drug company. Damages can include medical costs, income loss, and pain and suffering. Individuals who lose a loved one because of a drug defect may be able to file a wrongful death claim against the drug company.
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abilify may increase suicidal thoughts or behaviors in some children, teenagers, and young adults, especially within the first few months of treatment or when the dose is changed.